As reported by Brian Simm:

Grand Cayman checks in and out may only be made at Georgetown with the boat present for check-in. After that, the most sheltered anchorages in Grand Cayman are accessed from north sound and are in the residential canals and lagoons for boats of up to 2.5m or so draft. After entering north sound through the poorly marked main channel the main routes are accessible to 2.8 m.
Governor’s creek with the Cayman Islands marina is a large sheltered anchorage area at up to 4m. Entrance is buoyed at N19.21.45 W81.22.17. The marina has an outside dock for fuel and water.

Mitchell’s creek further in from Governor’s is accessible through the canals at 2.4m center channel and 2.2m in the anchorage. There is a mini marina with 3 or 4 catamarans, the owner, John’ has 4 moorings, white conical with a blue top band that he may allow cruisers to use free, otherwise free range anchoring area.

Further south from the main lagoon is the shopping center and marina of Camana bay; entrance from the sound at N19.19.48 W81.21.78 through a buoyed channel. This has been designed with dredged access of 1.7m. The channels are one way; with the north channel in and the south channel out. The very sheltered marina has a number of free slips on a first come first served basis and a moderate overnight charge-though they may not suit larger boats.

Further south still near the airport is a buoyed channel to Barcadere marina and at the very bottom of the sound is Harbour house marina which is a work yard with some mooring in a concrete channel. Both these latter have Marine chandleries.

Grand Cayman is a full duty-free stop for shipping in spare parts to boats in transit, 48 hr by air from UK or USA. Personal clearance for items can be made at the airport or more expensively via couriers. Also for booze, but the proviso for both is that customs officers must see goods onboard to boat.
Brian Simm

SV Scraatch, Sundeer 56

When arriving in Georgetown hail “Georgetown Port Security,” not Port Authority – they tend to not respond to anything but Port Security.